Yes you can. Please follow these steps:
- In the IPEVO Control Center, click the "Open Windows audio control panel" link at the bottom. The Audio Control panel for Windows OS appears.
- Select your choice of audio output/input device in the Audio Control panel and close it.
- Back in IPEVO Control Center, select FR-33.2 as the audio input/output/ringer device in the "Skype Audio Device" corner.
- From now on, only Skype calls will be handled by your FR-33.2.