Check the followings:
- Update the driver to the latest version.
- Make sure FR-33.2 is selected as the audio device in Skype (in Windows, Tools > Options > Audio Settings)
- Make sure the IPEVO Control Center (ICC) is activated. If the ICC icon does not appear in the bottom task bar, select Start button > Programs > IPEVO > IPEVO Control Center.
- If the screen says Skype is not activated, go to Skype and select Tools > Options > Advanced Settings and make sure ICC is allowed to access Skype API.